An Alternative and Efficient Route to Chlorophacinone
نویسندگان
چکیده
A rodenticide is any product able to kill rodents, mice, gophers, squirrels and other small animals. They represent a diverse group of chemicals bearing little or no relationship to one another – apart from their current or historic use as rodenticides. Anticoagulant rodenticides [1] of the indanedione type (Fig. 1) are commonly used for the control of mice, rats and other rodents. The most important one, chlorophacinone (1), is widely used in Europe, the Americas and Asia as a rodenticide pest control substance to control Rattus norvegicus (Norway rat, brown rat) and Mus musculus (house mouse). It is a first-generation anticoagulant rodenticide which disrupts the normal blood clotting mechanisms resulting in increased bleeding tendency and, eventually, profuses hemorrhage and interfers with vitamin K [2] in the ‘clotting cascade’ that involves many clotting factors. These anticoagulants are toxic [3] with LD50 values of a few mg kg−1 for rodents but also [1] for cats and dogs. Because of a significant difference in their water solubility the synthesis of chlorophacinone free of other phacinones especially of diphacinone (2) is important for its use in bait formulations.
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